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Friday, August 12, 2022
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Advanced Survival Analysis course - Leiden University Medical Center, August 29 - September 1, 2022


Please note that you must login (top right of the page) to see the materials and documents of the course.
Registered Participants have received a username/password


Visible information was updated:8 July 2022.

Course Location

The course takes place in the LUMC Education Building (Building 3) in room V4-18/22.
Route description | LUMC

All participants should bring their own laptop, with R pre-installed (see documentation). 


Travelling to and from Leiden Central Railway station (Dutch railway timetables )            

From Schiphol Airport 6 trains per hour leave from platform 5 or 6 for Leiden and the journey takes between 16 and 21 minutes.
Do not take a taxi! Much more expensive and slower than the train. 

If arriving by train from the direction of Germany, you can either travel to Schiphol and then onwards to Leiden or you can travel to Utrecht Central station and take a direct train (40 minutes every half hour) to Leiden.

From the direction of Belgium/France, you travel to either Rotterdam and continue with a normal intercity to Leiden or you travel to Schiphol and then southwards again to Leiden. International trains do not stop in Leiden.

On Monday 29th of August, we will have a joint dinner at restaurant ‘Proeflokaal Bregje’

From the LUMC, a 25 minute walk will take you to the restaurant. In the figure below, you can find an optional route showing how to get from the LUMC to ‘Proeflokaal Bregje’
Address Proeflokaal Bregje:
Breestraat 147, 2311 CN Leiden

Route Proeflokaal Bregje Leiden - Google Maps


General Information and documents

 TitleModified DateSize 
Course Location7/7/2022111.61 KBDownload
List of required R packages - 03/05/20195/4/201977.76 KBDownload
R Instructions4/24/201992.81 KBDownload


Monday 29 August
Location: room V4-18/22

 Time Teacher Lecture/Practical Topic Practical Assistents

8.45 – 9.00




9.00 – 09:45

Liesbeth de Wreede  Lecture

Introduction: Clinical background, Survival Analysis, pitfalls and solutions


09.45 – 10.30
10:45 – 11:15

Liesbeth de Wreede


Competing risks


11.15 – 12.30

Liesbeth de Wreede Practical Practical survival analysis/competing risks


12.30 – 13.30

Lunch break

13.30 – 14.15

Hein Putter  Lecture

Time-dependent Covariates in Cox Regression Models and landmarking


14.15 – 14.45
15:00 – 16:00

Hein Putter Lecture

Non-proportional hazards/pseudo-observations


16.00 – 17.00

Hein Putter Practical 

Practical Time-dependent covariates & non-proportional hazards/pseudo-observations

19.00                                Dinner ??

Tuesday 30 August  Location: room V4-18/22

 Time  Teacher  Lecture/Practical  Topic  Practical Assistents

9.00 – 09.30

Hein Putter

Discussion practicals Tuesday


09.30 – 11.15
(incl break)

Liesbeth de Wreede Lecture

Multi-state models


11.15 – 12.00

 Hein Putter Lecture  Dynamic prediction  

12:00 – 13:00

Lunch break

13.45  15.45

Hein Putter Lecture

Dynamic prediction


 13:45  15:45

(incl break)

 Liesbeth de Wreede/ Hein Putter  Lecture  Practical Multi-state models & Dynamic prediction  
 15:45 – 17:00 Hein Putter  Lecture  Frailty models I  

Wednesday 31 August
Location: room 

 Time Teacher   Lecture/Practical  Topic  Practical Assistents

9.00 – 09.30

Hein Putter 

Discussion practicals Wednesday


09.30 – 10.30

Hein Putter Lecture

Frailty models II

10:30 – 12:00
(incl break)

Hein Putter

Practical Frailty models


12.00 - 13.00

Lunch break

13.00 - 14.15

Lecture Joint models?


15.15 - 16.15

Nan van Geloven Lecture (+Practical)

Informative censoring/IPW


16.30 - 17.00

Nan van Geloven Lecture

Estimands in competing risks


Thursday 1 September
 Location: room 

 Time Teacher Lecture/Practical  Topic  Practical Assistents

9.00 – 10:00

Simona Iacobelli Lecture

Poisson models, multiple timescales



Simona Iacobelli Lecture / Demo

Illustration of models


11.30 – 12.30

Liesbeth de Wreede

Relative survival


12.30 - 13.30

Lunch break
 13.30 - 14.30 Liesbeth de Wreede Practical Practical Relative survival
 15.00 - 16.00  All Q&A

Liesbeth de Wreede 
Liesbeth de Wreede 

Henning Baldauf