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Tuesday, November 19, 2019
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Advanced Survival Analysis course - Leiden University Medical Center, 6-9 May 2019, Leiden, The Netherlands


Please note that you must login (top right of the page) to see the materials and documents of the course.
Registered Participants have received a username/password


Visible information was updated: May 2nd, 2019

Course Location

The course takes place in the LUMC, in room V4-18/22 (Monday, Wednesday and Thursday) and room V3-26/30 (Tuesday). 

All participants should bring their own laptop, with R pre-installed (see documentation). 

Travelling to and from Leiden Central Railway station ( Dutch railway timetables )


From Schiphol Airport 6 trains per hour leave from platform 5 or 6 for Leiden and the journey takes between 16 and 21 minutes. Do not take a taxi! Much more expensive and slower than the train. 

If arriving by train from the direction of Germany, you can either travel to Schiphol and then onwards to Leiden or you can travel to Utrecht Central station and take a direct train (40 minutes every half hour) to Leiden.

From the direction of Belgium/France, you travel to either Rotterdam and continue with a normal intercity to Leiden or you travel to Schiphol and then southwards again to Leiden. International trains do not stop in Leiden.


On Monday 6th of May, we will have a joined dinner at restaurant ‘Verboden Toegang’

From the LUMC, a 20 minute walk will take you to the restaurant. In the figure below, you can find an optional route showing how to get from the LUMC to ‘Verboden Toegang’.
Address: Kaiserstraat 7, 2311 GN, Leiden

General Information and documents

 TitleModified DateSize 
Course Location4/24/2019111.61 KBDownload
List of required R packages - 03/05/20195/4/201977.76 KBDownload
R Instructions4/24/201992.81 KBDownload


Monday 6th of May - Location: room V4-18/22

 Time Teacher Lecture/Practical Topic Practical Assistents

8.45 – 9.00




9.00 – 10.00

Liesbeth de Wreede  Lecture 1

Introduction: Clinical background, Survival Analysis, pitfalls and solutions


10.15 – 11.30

Liesbeth de Wreede

Lecture 2

Competing risks


11.45 – 12.45

Liesbeth de Wreede Practical 1 Practical survival analysis/competing risks

Edouard Bonneville,
Noor Tilman

12.45 – 13.45

Lunch break

13.45 – 14.45

Hein Putter  Lecture 3

Time-dependent Covariates in Cox Regression Models and landmarking


15.00 - 16.15

Hein Putter Lecture 4

Non-proportional hazards/pseudo-observations


16.15 – 17.00

Hein Putter Practical 2

Practical Time-dependent covariates & non-proportional hazards/pseudo-observations

Edouard Bonneville,
Damjan Manevski

19.00                                Dinner (Verboden Toegang, Location: Kaiserstraat 7, 2311 GN, Leiden)

 Tuesday 7th of May - Location: room V3-26/30

 Time  Teacher  Lecture/Practical  Topic  Practical Assistents

9.00 – 10.30

Liesbeth de Wreede Lecture 5

Multi-state models


10.45 – 12.15

Hein Putter Lecture 6

Dynamic prediction


12.15 – 13.15

Lunch break 

13:15 – 15:45

Liesbeth de Wreede,
Hein Putter 
Practical 3

Practical Multi-state models & Dynamic prediction

Katerina Bakunina

16.00 - 17.00

Hein Putter Lecture 7

Frailty models I


Wednesday 8th of May - Location: room V4-18/22

 Time Teacher   Lecture/Practical  Topic  Practical Assistents

9.00 – 10.00

Hein Putter  Lecture 8

Frailty models II


10.15 – 11.45

Hein Putter Practical 4

Practical Frailty models

Nan van Geloven, 
Edouard Bonneville

12:00 – 13:00

Henning Baldauf
Lecture 9

Survival analysis in clinical trials


13.00 - 14.00

Lunch break

14.00 - 15.00

Henning Baldauf
Practical 5 Practical Survival analysis in clinical trials


Bose Falk,
Katerina Bakunina

15.15 - 16.15

Nan van Geloven Lecture 10 (+Practical 6)

Informative censoring/IPW


16.30 - 17.00

Nan van Geloven Lecture 11

Estimands in competing risks


Thursday 9th of May - Location: room V4-18/22

 Time Teacher Lecture/Practical  Topic  Practical Assistents

9.00 – 10:00

Simona Iacobelli Lecture 12

Poisson models, multiple timescales



Simona Iacobelli Lecture 12/Demo 7

Illustration of models


11.30 – 12.30

Liesbeth de Wreede Lecture 13

Relative survival


12.30 - 13.30

Lunch break
 13.30 - 14.30 Damjan Manevski,
Liesbeth de Wreede
Practical 8 Practical Relative survival Damjan Manevski,
Dirk-Jan Eikema
 14.45 - 16.00  All Q&A

Liesbeth de Wreede 
Liesbeth de Wreede 

Henning Baldauf